Product Description

VGLL1 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-53198-60, E-AB-53198-120, E-AB-53198-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: VGLL1

Target Synonym: Protein TONDU; TDU; TONDU; Transcription cofactor vestigial like protein 1; Transcription cofactor vestigial-like protein 1; Vestigial like 1; vestigial like 1 homolog (Drosophila); Vgl-1; VGL1; Vgll1; VGLL1

Research Areas: Epigenetics and Nuclear Signaling

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human

Application: WB, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q99990

Background: The protein encoded by this gene binds proteins of the TEA domain family of transcription factors (TEFs) through the Vg (vestigial) homology region found in its N-terminus. It may thus function as a specific coactivator for the mammalian TEFs. TDU interacted directly with the TEA domain family member, TEF1, and deletion of the Vg homology region abolished the interaction. The TDU-TEF1 dimer activated a reporter plasmid, and expression of TDU in Drosophila rescued loss of Vg function. The interaction was stronger in cardiac myocytes, suggesting a myocyte-specific factor may participate in the interaction. Vgll1 was weakly active in driving expression of a reporter gene from the mouse skeletal muscle alpha-actin promoter, and Vgll1 could partially reverse the inhibitory effect of TEF1 in this assay.

Concentration: 2 mg/mL

Immunogen: Synthetic peptide of human VGLL1

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: WB 1:2000-1:10000 ELISA 1:2000-1:20000

Calculated MW: 29 kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only