VILIP-1 Monoclonal Antibody
Catalogue Numbers: MB67049-50, MB67049-100
Sizes: 50µl, 100µl
Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Swiss-Prot: P62760
Host: Mouse
Reactivity: Human
Applications: WB
All Applications: WB (1/1000 - 1/2000)
Background: Visinin-like Protein 1, also called VILIP-1 and VSNL1, is a calcium-sensing protein in the central nervous system. Visinin-like Protein 1 exhibits a widespread distribution with high expression in the CNS, and lower expression levels in some peripheral tissues . Visinin-like Protein 1 responds to increased intracellular calcium concentration by translocating from the cytoplasm to membranes through calcium-dependent myristoylation at its N-terminus that allows interaction with membranes . This change in localization has been proposed to facilitate the activation of compartment-specific signal transduction for the selective activation of downstream signaling cascades . In Alzheimer’s disease, Visinin-like Protein 1 expression is decreased in the brain, including a reduced number of Visinin-like Protein 1 immunoreactive neurons ; however, the presence of the protein is increased in the CSF , suggesting that it is released from neurons during insults.
Purification and Purity: This antibody is purified through a protein G column.
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Recognizes endogenous levels of VILIP-1 protein.
Extra Notes: Western blot analysis of VILIP-1 expression in human brain (A), human cerebellum (B) whole cell lysates.
Bioworld Molecular Weight: ~ 18 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Name: VISL1; Visinin-like protein 1; VILIP; VLP-1; Hippocalcin-like protein 3; HLP3
Immunogen: Recombinant fusion protein of human VILIP-1. The exact sequence is proprietary.
Conjugate: Unconjugated
Modification: Unmodified