Product Description

Vincμlin Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS67459-50, BS67459-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Vincμlin is a cytoskeletal protein that plays an important role in the regμlation of focal adhesions and embryonic development . Three structural vincμlin domains include an amino-terminal head, a short, flexible proline-rich region and a carboxy-terminal tail . In the inactive state, the head and tail domains of vincμlin interact to form a closed confirmation. The open and active form of vincμlin translocates to focal adhesions where it is thought to be involved in anchoring F-actin to the membrane and regμlation of cell migration . Phospholipid binding to the tail domain and subsequent phosphorylation of vincμlin at Ser1033 and Ser1045 by PKC-α and Tyr100 and Tyr1065 by Src kinases weakens the head-tail interaction . This change in vincμlin allows the binding of a number of other proteins, including talin, α-actinin and paxillin, which disrupts the head-tail interaction and initiates the conformational change from the inactive to active state. Vincμlin deficiencies are associated with a decrease in cell adhesion and an increase in cell motility, suggesting a possible role in metastatic growth . This is supported by a demonstrated relationship between decreased vincμlin expression and increased carcinogenesis and metastasis in colorectal carcinoma.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Chicken, Pig

Host: Rabbit

Applications: WB

Alternate Names: Vincμlin, Metavincμlin, MV

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Vincμlin. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of Vincμlin protein.

Molecular Weight: ~ 130 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P18206

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only