Product Description

Vitronectin Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66788-50, MB66788-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Fibronectin and Vitronectin are extracellμlar matrix glycoproteins that are present on most cell surfaces, in extracellμlar fluids, and in plasma. Both Fibronectin and Vitronectin have been shown to be involved in various functions including cell adhesion, cell motility and wound healing. Vitronectin contains an RGD (Arg-Gly-Asp acid) sequence that is present in many cell adhesion ligands. The RGD sequence has been shown to be essential for cell adhesion. Increased expression of Vitronectin, integrins and plasminogen activators has been observed in migrating cells during wound healing. Vitronectin has been shown to enhance smooth cell migration, and PAI-1 has been shown to bind to Vitronectin with high affinity, resμlting in the blocking of smooth cell migration. Glycosaminoglycans, proteins involved in the anchoring of Vitronectin to the extracellμlar matrix, have been shown to stimμlate the cleavage of Vitronectin by plasmin. This cleavage reduces the affinity of Vitronectin for PAI-1.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: Vitronectin, VN, S-protein, Serum-spreading factor, V75

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Vitronectin. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Specificity: Recognizes endogenous levels of Vitronectin protein.

Molecular Weight: ~ 65 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P04004

Product: Mouse IgM. Supplied in crude ascites with 0.01% sodium azide.

Research Use Only