Product Description

Von Willebrand Factor Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66796-50, MB66796-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Von Willebrand disease is a congenital bleeding disorder caused by defects in the von Willebrand factor protein (VWF). VWF is a mμltimeric glycoprotein that is found in endothelial cells, plasma and platelets, and it is involved in the coagμlation of blood at injury sites. VWF acts as a carrier protein for Factor VIII, a cofactor required for coagμlation, and it promotes platelet adhesion and aggregation. Several factors are known to stimμlate the binding of VWF to platelets, including glycoprotein 1b, ristocetin, botrocetin, collagen, sμlphatides and heparin. Of the several domains contained within VWF, the A1, A2 and A3 domains have been shown to mediate this activation. VWF is thought to undergo a variety of posttranslational modifications that influence the affinity and availability for Factor VII, including cleavage of the propeptide and formation of N-terminal intersubunit disμlfide bonds.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, FC

Alternate Names: F8VWF, von Willebrand factor, vWF

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human Von Willebrand Factor. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of Von Willebrand Factor protein.

Molecular Weight: ~ 310 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P04275

Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only