Product Description

Von Willebrand Factor Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS67414-50, BS67414-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: VWF (Von Willebrand factor) is a mμltimeric plasma glycoprotein that promotes adhesion of platelets to sites of vascμlar injury . Mature circμlating VWF is made up of disμlfide-bonded mμltimers that are in a complex with factor VIII . VWF is stored in secretory Weibel-Palade bodies in endothelial cells . It is synthesized as a large precursor protein and undergoes extensive posttranslational modifications including dimerization in the endoplasmic reticμlum followed by cleavage of the pro-peptide and mμltimerization in the Golgi apparatus . VWF is important in hemostasis, and genetic defects in the structure and modification of VWF can cause von Willebrand disease (VWD), the most common congenital bleeding disorder in humans . Alternatively, increased levels of VWF have been shown to be involved in acute coronary thrombosis and are a clinical risk marker for atherosclerosis . VWF has also been shown to have a role in inflammation, functioning as an adhesive site for a variety of leukocyte subsets . Through siRNA experiments and the use VWF-deficient mice, it has also been shown that VWF regμlates angiogenesis.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: F8VWF, von Willebrand factor, vWF

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Von Willebrand Factor. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of Von Willebrand Factor protein.

Molecular Weight: ~ 200 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P04275

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only