Product Description

VPS26 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91442-50, BS91442-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O75436(Human) P40336(Mouse) Q6AY86(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC, IP,

All Applications: WB:1:500-1:2,000
IHC:1:50-1:200
IP:1:10-1:50

Background: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. Required for retrograde transport of lysosomal enzyme receptor IGF2R. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Required for the endosomal localization of WASHC2A (indicative for the WASH complex). Required for the endosomal localization of TBC1D5. Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP. Involved in retromer-independent lysosomal sorting of F2R. Involved in recycling of ADRB2. Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: VPS26 polyclonal antibody detects endogenous levels of VPS26 protein.

Bioworld Molecular Weight: 38 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of VPS26 on different cell lysates using anti-VPS26 at 1/500 dilution.
Positive control:
Line 1: Rat kidney tissue
Line 2: A431, Immunohistochemical analysis of paraffin-embedded rat kidney tissue using anti-VPS26 antibody. Counter stained with hematoxylin.

Alternative Name: hVPS26, VPS26A, VPS26, FLJ12930, HB 58, HB58, Hbeta 58, Hbeta 58 homolog, Hbeta58, Hbeta58 homolog, hVPS 26, hVPS26, MGC94168, PEP 8A, PEP8A, Vacuolar protein sorting 26 A, Vacuolar protein sorting 26, Vacuolar protein sorting 26 homolog A, Vacuolar protein sorting 26 homolog A S. pombe, Vacuolar protein sorting 26 homolog A yeast, Vacuolar protein sorting 26 yeast, Vacuolar protein sorting 26 yeast homolog, Vacuolar protein sorting 26A, Vacuolar protein sorting associated protein 26A, Vacuolar protein sorting-associated protein 26A, Vesicle protein sorting 26, Vesicle protein sorting 26A, VP26A, VPS 26, VPS 26A, VPS26A,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodified