VRK1 Monoclonal Antibody-MB67186

VRK1 Monoclonal Antibody

Catalogue Numbers: MB67186-50, MB67186-100

Sizes: 50µl, 100µl

Product: Mouse IgG1. Supplied in crude ascites with 0.01% sodium azide.

Swiss-Prot: Q99986

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/500 - 1/2000)

Background: The vaccinia-related kinase (VRK) proteins are a new group of Ser/Thr kinases in the human kinome. This mammalian kinase family comprises three members, VRK1, VRK2, and VRK3. The VRK1 has autophosphorylation activity and phosphorylates several transcription factors, including p53, ATF2, and c-Jun. VRK2 is associated with the endoplasmic reticulum. VRK3 suppresses Erk activity through direct interaction and activation of the MAP kinase phosphatase VHR. Further functional and structural analysis of VRK proteins will elucidate important new aspects of cell regulation.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of VRK1 protein.

Extra Notes: Western blot analysis of VRK1 expression in Hela (A), HL60 (B) whole cell lysates.

Bioworld Molecular Weight: ~ 48 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Serine/threonine-protein kinase VRK1; Vaccinia-related kinase 1

Immunogen: Recombinant fusion protein of human VRK1. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified