Product Description

VWF Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91446-50, BS91446-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P04275(Human)

Host: Rabbit

Reactivity: Human

Applications: WB, IHC

All Applications: WB:1:1,000-1:5,000
IHC:1:50-1:200

Background: Von Willebrand disease is a congenital bleeding disorder caused by defects in the von Willebrand factor protein (VWF). VWF is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets, and it is involved in the coagulation of blood at injury sites. VWF acts as a carrier protein for Factor VIII, a cofactor required for coagulation, and it promotes platelet adhesion and aggregation. Several factors are known to stimulate the binding of VWF to platelets, including glycoprotein 1b, ristocetin, botrocetin, collagen, sulphatides and heparin. Of the several domains contained within VWF, the A1, A2 and A3 domains have been shown to mediate this activation. VWF is thought to undergo a variety of posttranslational modifications that influence the affinity and availability for Factor VII, including cleavage of the propeptide and formation of N-terminal intersubunit disulfide bonds.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: VWF polyclonal antibody detects endogenous levels of VWF protein.

Bioworld Molecular Weight: 309 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Von Willebrand Factor on human lung lysates using anti-Von Willebrand Factor antibody at 1/1,000 dilution., Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Von Willebrand Factor antibody. Counter stained with hematoxylin.

Alternative Name: vWF, Coagulation factor VIII, Coagulation factor VIII VWF, F8VWF, Factor VIII related antigen, von Willebrand antigen 2, von Willebrand antigen II, Von Willebrand disease, VWD, vWF, VWF,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified