Product Description

WASL Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91449-50, BS91449-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O00401(Human) Q91YD9(Mouse)

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, ICC IHC FC

All Applications: WB:1:500-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Background: This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression..

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: WASL polyclonal antibody detects endogenous levels of WASL protein.

Bioworld Molecular Weight: 55 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of WASL on mouse Human serum lysates using anti-Ubiquitin antibody at 1/500 dilution., ICC staining WASL in SK-Br-3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: N-WASP, WASP family, verprolin homology domain-containing protein 1, WASP family member 1, FLJ31482, homology of dictyostelium scar 1, KIAA0269, Protein WAVE-1 antibodyv Protein WAVE1, scar, Dictyostelium, homology of, 1, SCAR1, Similar to a plant extensin like protein, Verprolin homology domain containing protein 1, Verprolin homology domain-containing protein 1, WAS protein family, member 1, Wasf1, WASF1, WASL, WASP family 1, WASP family protein member 1, WASP family, verprolin homology domain-containing protein, WAVE, WAVE1, Wiskott Aldrich syndrome protein family member 1, Wiskott-Aldrich syndrome protein family member 1,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodified