Product Description

WBP2 Monoclonal Antibody

Catalogue Numbers: MB67170-50, MB67170-100

Sizes: 50µl, 100µl

Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: Q969T9

Host: Mouse

Reactivity: Human, Mouse

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: WW-domain binding protein 2 (WBP2) is an adaptor protein first identified in a screen for proteins that interact with YAP1. WBP2 was subsequently shown to bind other WW domain-containing proteins, including TAZ and NEDD4-like ubiquitin-protein ligases. There is strong evidence for a conserved functional role for WBP2 in the Hippo kinase tumor suppressor pathway. WBP2 interaction is required for the oncogenic properties of TAZ in breast cancer cells and the growth-promoting properties of the YAP homolog Yorkie in Drosophila. In vitro studies have also suggested that WBP2 may act as a transcriptional co-activator of both estrogen and progesterone receptors; this interaction was shown to be dependent upon tyrosine phosphorylation of WBP2 by c-Src and c-Yes kinases.

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of WBP2 protein.

Extra Notes: Western blot analysis of WBP2 expression in mouse heart (A), A549 (B), HL60 (C), 293 (D), A2058 (E) whole cell lysates.

Bioworld Molecular Weight: ~ 36 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: WW domain-binding protein 2; WBP-2

Immunogen: Recombinant fusion protein of human WBP2. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified