WDR1 Monoclonal Antibody-MB11779

WDR1 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11779-50, MB11779-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: O75083

Host: Rabbit

Reactivity: Human

Applications: WB, IHC-F, IHC-P, ICC/IF

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200

Background: Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458). Enhances cofilin-mediated actin severing . Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance . Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension . Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565).

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 66 kDa; Observed MW: 66 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of WDR1 in Jurkat lysates using WDR1 antibody., Immunohistochemistry analysis of paraffin-embedded Human Cholangiocarcinoma using WDR1 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval., Immunocytochemistry analysis of WDR1 in hela using WDR1 antibody, and DAPI

Alternative Name: AIP1; NORI-1; HEL-S-52

Immunogen: A synthetic peptide of human WDR1

Conjugate: Unconjugated

Modification: Unmodified