WDR79 Monoclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA12185-50, RA12185-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: WD repeat containing antisense to TP53 (WRAP53) Homo sapiens This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011], Reactivity: Human, Mouse, Rat Host: Mouse Applications: WB Alternate Names: WRAP53, TCAB1, WDR79, Telomerase Cajal body protein 1, WD repeat-containing protein 79, WD40 repeat-containing protein encoding RNA antisense to p53 Clonality: Monoclonal Dilution: Western Blot: 1/1000 - 1/2000. Not yet tested in other applications. Storage: -20°C/1 year Condition: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol. Human Gene ID: 55135 Research Use Only