Wnt-1 Polyclonal Antibody - RA21303

Wnt-1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA21303-50, RA21303-100

Citations, Manuals and MSDS Available upon request.

Background: Wnt family member 1 (WNT1) Homo sapiens The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Alternative Names: WNT1; INT1; Proto-oncogene Wnt-1; Proto-oncogene Int-1 homolog

Applications: WB; IHC-p; IF/ICC; ELISA

Species Cross-Reactivity: Human; Mouse

GeneID (Human): 7471

Protein MW (KDa): 45

SWISS: P04628

Source: Rabbit

Research Use Only