Product Description

Wnt11 Polyclonal Antibody

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Sizes: 50µl, 100µl

Catalogue Numbers: BS65434-50, BS65434-100

Swiss-Prot: O96014

Host: Rabbit

Wnt11 Polyclonal Antibody-BS65434

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,

Applications: WB,

All Applications: WB=1:500-2000

Background: The Wnt genes belong to a family of protooncogenes with at least 13 known members that are expressed in species ranging from Drosophila to man. The name Wnt denotes the relationship of this family to the Drosophila segment polarity gene ”wingless” and to its vertebrate ortholog, Int-1, a mouse proto-oncogene. Transcription of Wnt family genes appears to be developmentally regulated in a precise temporal and spatial manner. The Wnt genes encode cysteine-rich putative glycoproteins which have features typical of secreted growth factors. Wnt-11 is expressed in the tips of ureteric buds and in the perichondrium, a stem cell-like layer that surrounds the future bones and directs their growth and regeneration. Wnt-11 activity is required for cells to undergo correct convergent extension movements during gastrulation. Human Wnt-11 is also expressed in the lung mesenchyme, the urorectal septum, the urogenital folds, the labioscrotal swellings, and the cortex of the adrenal gland. Unlike other Wnt family members, Wnt-11 is not expressed in the neuroepithelium of the central nervous system. Wnt-11, along with Wnt-8c, is ex-pressed in the posterior region of the chick embryo in the caudal paraxial mesoderm that underlies the prospective caudal neural plate. The gene which encodes Wnt-11 maps to human chromosome 11q13.5.

Purification and Purity: affinity purified by Protein A

Specificity: Wnt11 Polyclonal Antibody detects endogenous levels of Wnt11 protein.

Bioworld Molecular Weight: 35 kD

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Primary: Anti- Wnt11 at 1/1000 dilution, Primary: Anti- Wnt11 at 1/1000 dilution

Alternative Name: HWNT11; Protein Wnt-11; Wingless-related MMt V integration site 11; Wingless-type MMt V integration site family, member 1; Wingless-type MMt V integration site family, member 11; Wingless-type MMt V integration site family, member 11B; wnt-11; wnt11b.WNT11_HUMAN

Immunogen: KLH conjugated synthetic peptide derived from human Wnt11:151-250/354

Modification: Unmodified

Conjugate: Unconjugated