WRN Rabbit Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA36208-50, RA36208-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: Werner syndrome RecQ like helicase (WRN) Homo sapiens This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008], Reactivity: Human, Rat, Mouse Host: Rabbit Applications: WB, ELISA Alternate Names: Werner syndrome ATP-dependent helicase (EC 3.6.4.12;DNA helicase, RecQ-like type 3;RecQ3;Exonuclease WRN;EC 3.1.-.-;RecQ protein-like 2) Clonality: Polyclonal Dilution: WB 1:1000-2000 ELISA 1:5000-20000 Storage: -20°C/1 year Human Gene ID: 7486 Human SwissProt Number: Q14191 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only