WWTR1 Polyclonal Antibody - BT-AP15563

WWTR1 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP15563-20, BT-AP15563-50, BT-AP15563-100

Citations, Manuals and MSDS Available upon request.

Background: Binds to transcription factors via its WW domain.,The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes.,Functions as a transcriptional coactivator.,PTM:Phosphorylated. Phosphorylation results in the inhibition of transcriptional coactivation through YWHAZ-mediated nuclear export.,Contains 1 WW domain.,subcellular location:Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ.,subunit:Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP.,tissue specificity:Highly expressed in kidney, heart, placenta and lung.,

Research Areas: Epigenetics and nuclear signaling; Stem cells

Target Protein: WWTR1

Applications: WB, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: WW domain-containing transcription regulator protein 1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q9GZV5; Mouse: Q9EPK5

Synonyms: WW domain-containing transcription regulator protein 1;Transcriptional coactivator with PDZ-binding motif

GeneID: Human: 25937

Research Use Only