Xanthine Oxidase Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS91457-50, BS91457-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P47989(Human) Q00519(Mouse) P22985(Rat)
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, IHC
All Applications: WB:1:500-1:2,000
IHC:1:50-1:200
Background: The process of metabolizing purines to a common molecule known as xanthine is an essential process for the proper shuttling of uric acid. Xanthine oxidase is a flavoprotein enzyme that coordinates molybdenum and utilizes NAD+ as an electron acceptor to catalyze the oxidation of hypoxanthine to xanthine and then to uric acid. The predominant form of this enzyme is xanthine dehydrogenase, which is a homodimer that can be converted to xanthine oxidase by sulfhydryl oxidation or proteolytic modification. Xanthine oxidase is present in species ranging from bacteria to human and is ubiquitously expressed in mammalian tissues. In the oxidase form, this enzyme is coupled to the generation of free radicals. Individuals showing marked elevation of serum xanthine oxidase is suggestive of chronic liver disease and cholestasis, which is a condition defined by hepatic obstruction. Hepatic obstruction causes bile salts, the bile pigment bilirubin, and fats to accumulate in the blood stream instead of being eliminated normally. The clinical consequences of defects in xanthine oxidase range from mild to severe and even contribute to fatal disorders.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Specificity: Xanthine Oxidase polyclonal antibody detects endogenous levels of Xanthine Oxidase protein.
Bioworld Molecular Weight: 146 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of Xanthine Oxidase on human kidney tissue lysate using anti-Xanthine Oxidase antibody at 1/1,000 dilution., Immunohistochemical analysis of paraffin-embedded rat liver tissue using anti-Xanthine Oxidase antibody. Counter stained with hematoxylin.
Alternative Name: XD, XO, XOR, XDH, XDHA, Xanthine dehydrogenase, Xanthine dehydrogenase/oxidase, Xanthine oxidase, Xanthine oxidoreductase, XD, XDH, XDH, xdha, XO, xor,
Immunogen: Recombinant protein within human Xanthine Oxidase aa 100-300.
Conjugate: Unconjugated
Modification: Unmodified