Product Description

XPB Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65890-50, BS65890-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Initiation of transcription from protein-coding genes in eukaryotes is a complex process that requires RNA polymerase II, as well as families of basal transcription factors. Binding of the factor TFIID (TBP) to the TATA box is believed to be the first step in the formation of a mμltiprotein complex containing several additional factors, including TFIIA, TFIIB, TFIIE, TFIIF and TFIIH. TFIIH (or BTF2) is a mμltisubunit transcription/DNA repair factor that possesses several enzymatic activities. The core of TFIIH is composed of 5 subunits, designated p89 (XPB or ERCC3), p62, p52, p44 and p34. Additional subunits of the TFIIH complex are p80 (XPD or ERCC2) and the ternary kinase complex composed of Cdk7, cyclin H and MAT1. Both p89 and p80 have ATP-dependent helicase activity. The p62, p52 and p44 subunits have been shown to be involved in nucleotide excision repair.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit

Host: Rabbit

Applications: IHC-P

Alternate Names: Basic transcription factor 2 89 kDa subunit, BTF 2, BTF2, BTF2 p89, DNA excision repair protein ERCC-3, DNA repair protein complementing XP-B cells, ERCC 3, ERCC3, ERCC3_HUMAN, Excision Repair Cross-complementing Rodent Repair deficiency complementation Group 3, GTF2H, RAD 25, RAD25, TFIIH 89 kDa subunit, TFIIH antibody TFIIH basal transcription factor complex 89 kDa subunit, TFIIH basal transcription factor complex helicase XPB subunit, TFIIH p89, Xeroderma pigmentosum group B-complementing protein.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human XPB/ERCC3:601-700/782

Dilution: IHC-P=1:100-500

Purification: affinity purified by Protein A

Specificity: XPB Polyclonal Antibody detects endogenous levels of XPB protein.

Molecular Weight: ~89kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -63°C long term. Avoid freeze-thaw cycles.

SwissProt: P19447

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only