XPD/ERCC2 Rabbit pAb - A5640

XPD/ERCC2 Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A5640-20, A5640-100

Citations, Manuals and MSDS Available upon request.

Background: The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Category: Polyclonal Antibodies

Applications: WB, IF/ICC, ELISA

Cross-reactivity: Human, Rat

Protein Weight: 87kDa

Observed Molecular Weight: 87kDa

Immunogen: Recombinant protein (or fragment) .

Species: Human

GeneID: 2068

SWISS: P18074

Alternate Names: EM9; TTD; XPD; TTD1; COFS2; TFIIH; XPD/ERCC2

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:2000 IF/ICC, 1:50 - 1:100 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Research Areas: Epigenetics Nuclear Signaling, DNA Damage Repair, Cell Biology Developmental Biology, Apoptosis.

NCBI Alias: ERCC2

Research Use Only