Product Description

XPLN Polyclonal Antibody

Catalogue Numbers: BS62461-50, BS62461-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Swiss-Prot: Q9NR81

Host: Rabbit

Reactivity: Human

Applications: WB IHC ICC

All Applications: WB:1:500~1:1000 IHC:1:50~1:200 ICC:1:50~1:200

Background: Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Purification and Purity: The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.

Specificity: XPLN polyclonal antibody detects endogenous levels of XPLN protein.

Extra Notes: Western blot analysis of extracts of human brain line, using XPLN polyclonal antibody.

Bioworld Molecular Weight: ~ 55 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: GEF3; STA3; XPLN

Immunogen: Synthetic peptide, corresponding to Human XPLN.

Conjugate: Unconjugated

Modification: Unmodified