XPO4 Monoclonal Antibody-MB10896

XPO4 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB10896-50, MB10896-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q9C0E2

Host: Rabbit

Reactivity: Human, Rat

Applications: WB,IP

All Applications: WB: 1/500-1/1000 IP: 1/20

Background: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Exportin 4 in MCF-7, C6Lysates using XPO4 antibody.

Bioworld Molecular Weight: Calculated MW: 130 kDa; Observed MW: 130 kDa

Specificity: IgG

Alternative Name: exp4

Immunogen: A synthetic peptide of human Exportin 4

Conjugate: Unconjugated

Modification: Unmodified