XRCC1 (G552) Polyclonal Antibody-BS1493

XRCC1 (G552) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS1493-50, BS1493-100

Sizes: 50µl, 100µl

Swiss-Prot: P18887

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

Background: The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC1 is a 70 kDa protein that facilitates the DNA base excision repair pathway by interacting with DNA ligase III and DNA polymerase to repair DNA single-strand breaks. XRCC2 and XRCC3 are both involved in maintaining chromosome stability during cell division. XRCC2 is required for efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids, and XRCC3 interacts directly with Rad51 to cooperate with Rad51 during recombinational repair. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in v (D)J recombination.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: XRCC1 (G552) polyclonal antibody detects endogenous levels of XRCC1 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of XRCC1 (G552) polyclonal antibody at 1:500 dilution
Lane 1: HepG2 whole cell lysate
Lane 2: Raw264.7 whole cell lysate
Lane 3: H9C2 whole cell lysate, Immunohistochemistry (IHC) analyzes of XRCC1 (G552) pAb in paraffin-embedded human lung carcinoma tissue at 1:100.

Bioworld Molecular Weight: ~ 80 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: XRCC1; X-ray repair cross-complementing protein 1; XRCC1; XRCC1. XRCC 1. XRCC-1. X-ray cross complementing factor X ray. DNA ligase. complementation protein

Immunogen: Synthetic peptide, corresponding to amino acids 520-570 of Human XRCC1.

Conjugate: Unconjugated

Modification: Unmodified