XRCC1 rabbit pAb - ES3713

XRCC1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES3713-50, ES3713-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008],

Alternate Name: XRCC1; DNA repair protein XRCC1; X-ray repair cross-complementing protein 1

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human XRCC1. AA range:517-566

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 70kD

Human Gene ID: 7515

Human SWISS Prot NO: P18887

Subcellular Location: Nucleus. Moves from the nucleoli to the global nuclear chromatin upon DNA damage.

Research Use Only