XRCC4 (7C10) Monoclonal Antibody-MB3188

XRCC4 (7C10) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB3188-50, MB3188-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: Q13426

Host: Mouse

Reactivity: Human, Mouse, Rat

Applications: WB, IHC-F, IHC-P, ICC/IF, IP,

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/20

Background: Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG1

Bioworld Molecular Weight: Calculated MW: 38 kDa; Observed MW: 38-45 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry analysis of paraffin-embedded XRCC4 in Human lung cancer using XRCC4 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval., Western blot analysis of XRCC4 in XRCC4 in T47D, 3T3, COS7, C6 and Hela lysates using XRCC4 antibody, Immunoprecipitation analysis of XRCC4 in Hela lysates using XRCC4 antibody.

Alternative Name: X ray repair cross complementing protein 4; DNA repair protein XRCC4; DNA double strand break repair

Immunogen: Synthetic Peptide of XRCC4

Conjugate: Unconjugated

Modification: Unmodified