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XRCC5 (8H1) Monoclonal Antibody-MB0183

XRCC5 (8H1) Monoclonal Antibody-MB0183

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XRCC5 (8H1) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB0183-50, MB0183-100

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P13010

Host: Mouse

Reactivity: Human, Monkey

Applications: WB, IF, IP,

All Applications: WB: 1:1000
IP: 1:50~200
IF: 1:100~500

Background: XRCC5 encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Purification and Purity: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This antibody detects endogenous levels of XRCC5 and does not cross-react with related proteins.

Bioworld Molecular Weight: Predicted band size: 86KDa
Observed band size: 86KDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot detection of XRCC5 in COS7,Jurkat,Hela,MCF7 and A549 cell lysates using XRCC5 mouse mAb (1:1000 diluted)., Immunofluorescent analysis of Hela cells using XRCC5 mouse mAb (1:400)., Immunoprecipitation analysis of Hela cell lysates using XRCC5 mouse mAb.

Alternative Name: X-ray repair cross-complementing protein 5; 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; Ku80; Ku86; Ku-80; Ku-86; Lupus Ku autoantigen protein p86; Nuclear factor IV; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); XRCC5; G22P2

Immunogen: Purified recombinant human XRCC5 protein fragments expressed in E.coli.

Conjugate: Unconjugated

Modification: Unmodified