Product Description

XRN1 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB67147-50, MB67147-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: 5’-3’ exoribonuclease 1 (XRN1) is a cytoplasmic exonuclease that degrades RNA containing a 5’-monophosphate to component mononucleotides. XRN1 is the primary exonuclease associated with ribosomes in the cytoplasm and is responsible for mRNA turnover. This turnover is facilitated in discrete structures in the cytoplasm called P-bodies that contain decapping and deadenylation proteins. XRN1 also plays a role in RISC-mediated mRNA degradation, as it associates with 3’ mRNA fragments generated by RISC cleavage. This process does not require uncapping or deadenylation. XRN1 plays a significant role in viral RNA degradation. As such, many viral genomes, including hepatitis C, Dengue, and West Nile, encode for XRN1-resistant long non-coding RNA that affect innate immunity and viral replication.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: SEP1, 5'-3' exoribonuclease 1, Strand-exchange protein 1 homolog

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human XRN1. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of XRN1 protein.

Molecular Weight: ~ 200 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8IZH2

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only