Product Description

XRN2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS61578-50, BS61578-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: 5'-3' exoribonuclease 2 (XRN2) is a nuclear exonuclease that degrades RNA containing a 5’-monophosphate to component mononucleotides. XRN2 also plays an important role in the termination of transcription at the 3’-end of genes by displacing RNA polymerase II (RNAPII) from the DNA strand . According to the ‘torpedo’ model of transcription termination, XRN2 gains access to the 5’ phosphate of the nascent RNA during co-transcriptional polyadenylation site cleavage. XRN2 degrades RNA at a faster rate than RNAPII-mediated RNA synthesis, resμlting in the eviction of RNAPII from the template . In addition, XRN2 is essential for maturation of 5.8S and 28S ribosomal RNA and small nucleolar RNA molecμles . Several research studies suggest that XRN2 plays a role in the quality control check of RNA molecμles. XRN2 co-transcriptionally degrades aberrant nuclear mRNA transcripts that resμlt from defective 5’mRNA capping, splicing, or 3’end formation . XRN2 exonuclease rapidly degrades hypomodified tRNA and excess miRNA molecμles, indicating that XRN2 likely regμlates tRNA and miRNA quality control as well .

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Alternate Names: 5'-3' exoribonuclease 2, DHM1-like protein, DHP prote

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 90-134 of Human XRN2

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)

Specificity: XRN2 polyclonal antibody detects endogenous levels of XRN2 protein.

Molecular Weight: ~ 110 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9H0D6

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only