Product Description

YTHDC2 Rabbit Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66466-50, MB66466-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: YTH domain-containing protein 1 (YTHDC1) and YTH domain-containing protein 2 (YTHDC2) both belong to a family of proteins that bind to RNA. YTHDC1 and YTHDC2 both recognize and bind to N6-methyladenosine(m6A)-containing RNAs, binding is mediated through the YTH domains . m6A is a modification that is present at internal sites of mRNAs and some non-coding RNAs and plays a role in regμlating mRNA splicing, processing, and stability. YTHDC1, also known as splicing factor YT521, regμlates alternative splicing by functioning as a key regμlator of exon-inclusion or exon-skipping. YTHDC1 promotes exon-inclusion by recruiting pre-mRNA splicing factor SRSF3 to regions containing m6A, while repressing exon-skipping by blocking SRSF10 binding to these same regions. Increased expression of YTHDC1 promotes malignant endometrial carcinoma (EC) through alternative splicing of vascμlar endothelial growth factor A (VEGF-A), resμlting in an increase in VEGF-165 isoform and increased EC cell invasion. YTHDC2 functions to enhance the translation efficiency of target mRNAs and may play a role in spermatogenesis.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, IP

Alternate Names: Probable ATP-dependent RNA helicase YTHDC2

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant protein of mouse YTHDC2

Dilution: WB (1/500 - 1/1000), IP (1/10 - 1/50)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of YTHDC2 protein.

Molecular Weight: ~ 160 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9H6S0

Product: Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Research Use Only