Product Description

YY1 Polyclonal Antibody

Catalogue Numbers: BS67357-50, BS67357-100

Sizes: 50µl, 100µl

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: P25490

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB (1/500 - 1/2000)

Background: YY1 (Yin Yang1) is a ubiquitously expressed transcription factor with fundamental roles in embryogenesis, differentiation, replication and proliferation. YY1 contains four zinc finger motifs of the Cys-Cys-His-His type and can activate different eukaryotic genes (such as CREB, c-myc, Histone H4, p53 and PARP-1) or repress different eukaryotic genes (such as α-actin, IFN-β and IFN-γ) as well as regulate some viral promoters. YY1 deficient embryos die approximately at the time of implantation, suggesting that YY1 has an essential role in embryonic development. YY1 is overexpressed in cancer cells such as prostate cancer and therefore may be considered a prognostic marker.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of YY1 protein

Extra Notes: Western blot analysis of YY1 expression in Jurkat (A) whole cell lysates.

Bioworld Molecular Weight: ~ 68 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: INO80S; Transcriptional repressor protein YY1; Delta transcription factor; INO80 complex subunit S; NF-E1; Yin and yang 1; YY-1

Immunogen: Recombinant fusion protein of human YY1. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified