Product Description

ZAC Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS62528-50, BS62528-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Pleiomorphic adenoma gene (PLAG1) encodes a zinc finger protein and is the target gene for pleiomorphic adenomas of the salivary gland. The PLAG family of zinc finger proteins include PLAG1, ZAC1 and PLAG-like 2 (PLAGL2). ZAC1, also known as PLAGL1, concomitantly controls apoptosis and cell cycle arrest through separate pathways. ZAC1 also acts as a positive or negative transcriptional cofactor for nuclear receptors, depending on the expression of functional p53. ZAC1 is broadly expressed in embryo, with highest expression in the liver primordium, the umbilical region and the neural tube. PLAGL1 is also expressed in normal mammary gland. PLAGL2 functions as a positive regμlator of transcription and localizes to the nucleus. PLAGL2 and ZAC1 bind to the DNA consensus sequence ACGGGGGCCCCTTTA. PLAGL2 is ubiquitously expressed with particμlar abundance in spleen, lung and testis where it may be involved in cell cycle arrest and apoptosis of tumor cells.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Zinc finger protein PLAGL1, Lost on transformation 1, LOT-1, Pleiomorphic adenoma-like protein 1, Tumor suppressor ZAC, PLAGL1, LOT1, ZAC

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to Human ZAC.

Dilution: WB:1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: ZAC polyclonal antibody detects endogenous levels of ZAC protein.

Molecular Weight: ~ 51 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9UM63

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only