Product Description

ZC3HC1 (Phospho-S354) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS64402-50, BS64402-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: NIPA (nuclear interaction partner of ALK) is an F-box-containing protein that is an essential component of the SCF-type E3 ligase (SCFNIPA) complex, a complex that controls the completion of S-phase and mitotic entry . This control is mediated by the ubiquitination and subsequent degradation of cell cycle regμlatory proteins, whose oscillation of protein levels is required for proper cell cycle progression. Expression levels of NIPA are low in G0/G1 phases and upregμlated in S and G2/M phases. The SCFNIPA complex targets nuclear cyclin B1 for ubiquitination in interphase, whereas phosphorylation of NIPA in late G2 phase and mitosis inactivates the complex to allow for accumμlation of cyclin B1. NIPA may have an anti-apoptotic role in NPM-ALK-mediated signaling events.

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Nuclear-interacting partner of ALK, Nuclear-interacting partner of anaplastic lymphoma kinase, hNIPA, Zinc finger C3HC-type protein 1, ZC3HC1, NIPA, HSPC216

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human ZC3HC1 around the phosphorylation site of Serine 354.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: ZC3HC1(Phospho-S354) polyclonal antibody detects endogenous levels of ZC3HC1 protein only when phosphorylated at Ser354.

Molecular Weight: ~ 65kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q86WB0

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only