Product Description

ZFAND5 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-90603-60, E-AB-90603-120, E-AB-90603-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: ZFAND5

Target Synonym: ZFAND5; ZA20D2; ZFAND5A; ZNF216

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Mouse

Application: WB

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: O76080

Background: Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF, IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human ZFAND5

Buffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.

Purification Method: Affinity purification

Dilution: WB 1:500-1:1000

Calculated MW: 23kDa

Observed MW: 23kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only