Product Description

ZNF354A Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-52385-60, E-AB-52385-120, E-AB-52385-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: ZNF354A

Target Synonym: EZNF; HKL1; HLK1; Homo sapiens zinc finger protein 354A; KID 1; KID1; Kidney; ischemia; and developmentally regulated protein 1; Renal transcription factor Kid 1 ; TCF-17; TCF17; Transcription factor 17; Z354A; Zinc finger protein 354A; Zinc finger protein eZNF; ZNF354A

Research Areas: Epigenetics and Nuclear Signaling, Neuroscience

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: IHC, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: O60765

Background: ZNF354A, also called EZNF, KID-1 or TCF17, belongs to the Krüppel C2H2-type zinc-finger family of proteins that contain KRAB domains and act as transcriptional regulators. Expressed primarily in the adult kidney, ZNF354A is a transcriptional repressor that plays a role in late renal development and is suppressed after renal ischemia. The N-terminus of ZNF354A contains the KRAB domain which confers transcriptional repressor activity, while the C-terminus contains multiple Cys2His2-zinc fingers. ZNF354A is located in the nucleolus and is thought to specifically influence development of the proximal tubule by shutting off dispensable or inhibitory genes. Reduced ZNF354A expression prevents proper cell differentiation and may, therefore, be implicated in renal carcinoma.

Concentration: 0.5 mg/mL

Immunogen: Fusion protein of human ZNF354A

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only