Product Description

ZNF423 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65568-50, BS65568-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: OAZ is a 30-zinc finger, DNA-binding factor that associates with members of the Smad family of transcription factors in response to BMP2 activation. Bone morphogenic proteins (BMPs), are the largest group within the TGF∫ growth factors superfamily and are involved in embryonic development, specifically the formation of left-right asymmetry, neurogenesis, organogenesis and skeletal development. BMPs bind to surface receptors, which then phosphorylate serine residues of specific Smad proteins to induce Smad translocation to the nucleus and transcriptional activation of BMP targeted genes. OAZ specifically cooperates with the BMP-activated Smads, namely Smad1, 5 and 8, in binding to the CAGAC and TGGAGC boxes within the BRE, or BMP response element, and activating transcription. OAZ contains a BMP signaling modμle formed by two clusters of fingers that individually associate with either the Smads or the BMP response element. Distinct regions of OAZ, separate from the modμles involved in BMP regμlation, also enable OAZ to function as a transcriptional partner of Olf-1/EBF in olfactory epithelium and lymphocyte development, indicating that, as a mμlti–zinc finger protein, OAZ may have dual roles in signal transduction during development.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC-P

Alternate Names: Early B cell factor associated zinc finger protein, Ebfaz, hOAZ, Nur12, OAZ, OLF 1/EBF associated zinc finger, OLF1/EBF associated zinc finger protein, Olf1/EBF-associated zinc finger protein, Roaz, Smad and Olf interacting zinc finger protein, Smad- and Olf-interacting zinc finger protein, Zfp104, ZFP423, zinc finger protein 423, mouse, homolog of, Zinc finger protein 423, ZN423_HUMAN, ZNF423, ZNF423 zinc finger protein 423.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human ZNF423 :191-290/1284

Dilution: WB=1:500-2000 IHC-P=1:400-800 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations shoμld be determined by the end user.

Purification: affinity purified by Protein A

Specificity: ZNF423 polyclonal Antibody detects endogenous levels of ZNF423 protein.

Molecular Weight: ~145kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q2M1K9

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only