Product Description

ZNF462 Polyclonal Antibody

Catalogue Numbers: BS60800-50, BS60800-100

Sizes: 50µl, 100µl

Alternative Name: Zinc finger protein 462; ZNF462; KIAA1803

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q96JM2

Host: Rabbit

Reactivity: Human, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1,thereby recruiting histone modifying proteins. ZNF462 (zinc finger protein 462) is a 2,506 amino acid protein that localizes to nucleus and is subject to posttranslational phosphorylation upon DNA damage, possibly by ATM or ATR.Containing twenty-seven C2H2-type zinc finger motifs and existing as multiple alternatively spliced isoforms, ZNF462 is encoded by a gene located on human chromosome 9q31.2. Chromosome 9 consists of about 145 million bases, 4% of the human genome and encodes nearly 900 genes. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects,and Familial dysautonomia, are both associated with chromosome 9.Notably, chromosome 9 encompasses the largest interferon family gene
cluster.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ZNF462 polyclonal antibody detects endogenous levels of ZNF462 protein.

Bioworld Molecular Weight: ~ 285 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of ZNF462 polyclonal antibody at 1:500 dilution
Lane 1: A549 whole cell lysate
Lane 2: PC12 whole cell lysate

Immunogen: A synthetic peptide corresponding to residues in Human ZNF462.

Conjugate: Unconjugated

Modification: Unmodified