ZNF638 Polyclonal Antibody-BS5827

ZNF638 Polyclonal Antibody

Catalogue Numbers: BS5827-50, BS5827-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q14966

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. NP220 (Nuclear protein 220), also designated Zinc finger protein 638 (ZNF638) or Cutaneous T-cell lymphoma-associated antigen se33-1, is a 1978 amino acid protein that contains one matrin-type zinc finger and two RRM (RNA recognition motif) domains, suggesting a role in transcriptional regulation. NP220 binds to double-stranded DNA fragments by recognizing clusters of cytidines. NP220 interacts with FHL-2 and is also thought to be phosphorylated by ATM or ATR upon DNA damage. It exists as five isoforms as a result of alternative splicing events. Isoform five of NP220 is a tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and in particular in mycosis fungoides patients and in Sezary syndrome patients.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ZNF638 polyclonal antibody detects endogenous levels of ZNF638 protein.

Extra Notes: Western blot (WB) analysis of ZNF638 pAb at 1:500 dilution
Lane1:PC3 whole cell lysate(40ug)
Lane2:A549 whole cell lysate(40ug)
Lane3:HEK293T whole cell lysate(40ug)
Lane4:The brain tissue lysate of Rat(40ug)
Lane5:The brain tissue lysate of Mouse(40ug)

Bioworld Molecular Weight: ~ 230kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Zinc finger protein 638; Cutaneous T-cell lymphoma-associated antigen se33-1; CTCL-associated antigen se33-1; Nuclear protein 220; Zinc finger matrin-like protein; NP220; ZFML

Immunogen: Synthetic peptide, corresponding to amino acids 1308-1353 of Human ZNF638.

Conjugate: Unconjugated

Modification: Unmodified