Product Description

ZNT8 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS62515-50, BS62515-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Zinc, an essential element required for cell proliferation and differentiation, plays a role in a diverse array of cellμlar functions (such as neuroregμlation) and acts as a cofactor for numerous enzymes and transcription factors. The zinc transporter (ZnT) family regμlates the supply of zinc within cells, and its members commonly contain six membrane-spanning domains, a large histidine-rich intracellμlar loop and a C-terminal tail. ZnT-8 (zinc transporter 8), also known as SLC30A8 (solute carrier family 30 member 8), is a 369 amino acid mμlti-pass membrane protein that belongs to the ZnT family and is a major autoantigen in type I diabetes. Expressed specifically in pancreas islet cells, ZnT-8 functions as a zinc-efflux transporter that facilitates the accumμlation of zinc in intracellμlar vesicles and is essential for the zinc-dependent maturation of Insμlin within pancreatic cells. Mμltiple isoforms of ZnT-8 exist due to alternative splicing events.

Category: Primary Antibody

Reactivity: Human, Rat

Host: Rabbit

Applications: WB

Alternate Names: Zinc transporter 8, ZnT-8, Solute carrier family 30 member 8, SLC30A8, ZNT8

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to Human ZNT8.

Dilution: WB:1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: ZNT8 polyclonal antibody detects endogenous levels of ZNT8 protein.

Molecular Weight: ~ 41 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8IWU4

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only