β-Catenin Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A11932-20, A11932-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
Category: Polyclonal Antibodies
Applications: WB, IHC-P, IF/ICC, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 85kDa
Observed Molecular Weight: 100kDa
Immunogen: Synthetic peptide
Species: Human
GeneID: 1499
SWISS: P35222
Alternate Names: EVR7; CTNNB; MRD19; NEDSDV; armadillo; β-Catenin
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 IHC-P, 1:50 - 1:200 IF/ICC, 1:50 - 1:100 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, Protein phosphorylation, Cancer, Invasion and Metastasis, Signal Transduction, ErbB-HER Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Cell Adhesion, Cadherins, Tight Junctions, Cytoskeleton, Microfilaments, Wnt -Catenin Signaling Pathway, ESC Pluripotency and Differentiation, Immunology Inflammation, Neuroscience, Stem Cells, Cardiovascular, Angiogenesis.
NCBI Alias: CTNNB1
Research Use Only