Alpha-2-Macroglobulin (A2M) Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A1573-20, A1573-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 163kDa
Observed Molecular Weight: 163kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 2
SWISS: P01023
Alternate Names: A2MD; CPAMD5; FWP007; S863-7; Alpha-2-Macroglobulin (A2M)
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Cell Biology Developmental Biology, Ubiquitin, Cardiovascular, Blood, Serum Proteins.
NCBI Alias: A2M
Research Use Only