ALS2 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A7125-20, A7125-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.
Category: Polyclonal Antibodies
Applications: WB, IF/ICC, IF-P, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 184kDa
Observed Molecular Weight: 184kDa
Immunogen: Recombinant protein (or fragment) .
Species: Human
GeneID: 57679
SWISS: Q96Q42
Alternate Names: ALSJ; PLSJ; IAHSP; ALS2CR6; ALS2
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 IF/ICC, 1:50 - 1:200 IF-P, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Cell Biology Developmental Biology, Cell Cycle, Centrosome, Neuroscience, Neurodegenerative Diseases, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease, Neurodegenerative Diseases Markers.
NCBI Alias: ALS2
Research Use Only