APC Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A2818-20, A2818-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers, where disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Category: Polyclonal Antibodies
Applications: WB, IHC-P, IF/ICC, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 312kDa
Observed Molecular Weight: 150kDa
Immunogen: Recombinant protein (or fragment) .
Species: Human
GeneID: 324
SWISS: P25054
Alternate Names: GS; DP2; DP3; BTPS2; DESMD; DP2.5; PPP1R46; APC
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 IHC-P, 1:50 - 1:200 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, Cancer, Tumor suppressors, Signal Transduction, Cell Biology Developmental Biology, Apoptosis, Cell Cycle, Centrosome, Cell Adhesion, Microtubules, Wnt -Catenin Signaling Pathway, ESC Pluripotency and Differentiation, Neuroscience, Cell Type Marker, Stem Cells, Cardiovascular, Heart, Cardiogenesis.
NCBI Alias: APC
Research Use Only