APEX1/APE1 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A1117-20, A1117-100
Citations, Manuals and MSDS Available upon request.
Background: The APEX gene encodes the major AP endonuclease in human cells. It encodes the APEX endonuclease, a DNA repair enzyme with apurinic/apyrimidinic (AP) activity. Such AP activity sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. The AP sites are the most frequent pre-mutagenic lesions that can prevent normal DNA replication. Splice variants have been found for this gene; all encode the same protein. Disruptions in the biological functions related to APEX are associated with many various malignancies and neurodegenerative diseases.
Category: Polyclonal Antibodies
Applications: WB, IF/ICC, ELISA
Cross-reactivity: Human
Protein Weight: 36kDa
Observed Molecular Weight: 39kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 328
SWISS: P27695
Alternate Names: APE; APX; APE1; APEN; APEX; HAP1; REF1; APEX1/APE1
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 IF/ICC, 1:50 - 1:100 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, DNA Damage Repair, Cardiovascular, Heart, Cardiogenesis.
NCBI Alias: APEX1
Research Use Only