Cathepsin L/V/K/H Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A12200-20, A12200-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Human, Rat
Protein Weight: 38kDa
Observed Molecular Weight: 38kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 1514
SWISS: P07711
Alternate Names: MEP; CATL; CTSL1; Cathepsin L/V/K/H
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:1000 - 1:5000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Cell Adhesion, Cytoskeleton, Extracellular Matrix, Neuroscience.
NCBI Alias: CTSL
Research Use Only