Chicken IL12B Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A25100-20, A25100-100
Citations, Manuals and MSDS Available upon request.
Background: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Gallus
Protein Weight: 36kDa
Observed Molecular Weight: 45kDa
Immunogen: Recombinant protein (or fragment) .
Species: Gallus
GeneID: 404671
SWISS: Q6X0K9
Alternate Names: IL-12B; IL-12p40
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Immunology, Innate, Immunity, Cytokines, Interleukins.
NCBI Alias: IL12B
Research Use Only