CRLF2 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A10152-20, A10152-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 42kDa
Observed Molecular Weight: 50kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 64109
SWISS: Q9HC73
Alternate Names: CRL2; TSLPR; CRLF2Y; CRLF2
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:200 - 1:1000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Immunology Inflammation, Cytokines, Cell Intrinsic Innate Immunity Signaling Pathway.
NCBI Alias: CRLF2
Research Use Only