Daxx Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A1642-20, A1642-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Human, Mouse
Protein Weight: 81kDa
Observed Molecular Weight: 110kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 1616
SWISS: Q9UER7
Alternate Names: DAP6; EAP1; BING2; SMIM40; Daxx
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling, Chromatin Remodeling, Signal Transduction, MAPK-JNK Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Death Receptor Signaling Pathway, Neuroscience, Neurodegenerative Diseases.
NCBI Alias: DAXX
Research Use Only