DKK1 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A2562-20, A2562-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 29kDa
Observed Molecular Weight: 28-45kDa
Immunogen: Recombinant protein (or fragment) .
Species: Human
GeneID: 22943
SWISS: O94907
Alternate Names: SK; DKK-1; DKK1
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Cell Biology Developmental Biology, Growth factors, Wnt -Catenin Signaling Pathway, Immunology Inflammation, Stem Cells, Cardiovascular, Blood.
NCBI Alias: DKK1
Research Use Only