eIF2α Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A0764-20, A0764-100
Citations, Manuals and MSDS Available upon request.
Background: The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 36kDa
Observed Molecular Weight: 36kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 1965
SWISS: P05198
Alternate Names: EIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha; eIF2α
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:1000 - 1:5000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling, RNA Binding, Translation Control, Protein phosphorylation, Cell Biology Developmental Biology.
NCBI Alias: EIF2S1
Research Use Only