EIF4G1 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A7552-20, A7552-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly (A) -binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.
Category: Polyclonal Antibodies
Applications: WB, IHC-P, IP, ELISA
Cross-reactivity: Human
Protein Weight: 175kDa
Observed Molecular Weight: 220kDa
Immunogen: Synthetic peptide .
Species: Human
GeneID: 1981
SWISS: Q04637
Alternate Names: P220; EIF4F; EIF4G; EIF4GI; PARK18; EIF-4G1; EIF4G1
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:100 - 1:500 IHC-P, 1:50 - 1:200 IP, 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling, RNA Binding, Translation Control, Regulation of eIF4 and p70 S6 Kinase, Protein phosphorylation, Signal Transduction, PI3K-Akt Signaling Pathway, Immunology Inflammation.
NCBI Alias: EIF4G1
Research Use Only